The effects of oral cimetidine on food stimulated gastric acid secretion and 24 hour intragastric acidity

Four series of studies were performed to determine the effects of oral cimetidine on gastric function stimulated by food or by normal daily activity. Fifteen healthy subjects and ten patients with duodenal ulceration were investigated: oral cimetidine decreased the gastric acid secretion and/or intragastric acidity of all 25 subjects. Cimetidine 200 mg inhibited the acid secretion in response to a protein meal by a mean of 62%. Studies of 24 …