Hemopoietic mechanisms in nasal polyposis and asthma

In nasal polyposis and asthma, there are consistent increases in eosinophil and basophil (Eo-B) progenitors in blood and bone marrow. IL-5 plays a central role in Eo-B differentiation, exerting its effects through the IL-5 receptor expressed on Eo-B progenitors which can be found not only in blood and bone marrow but also within airway tissues such as nasal polyps and asthmatic bronchial mucosa. Little is currently known concerning regulation …