Journal article
Relationship Between Transcription Factors and S14 Gene Expression in Response to Thyroid Hormone and Age
Abstract
In this report, we have examined the effect of aging on thyroid hormone regulated S14 gene expression by comparing levels of the mRNA in the liver of young (6-month) and aged (26-month) rats of various thyroid states. Although levels of mRNA-S14 were stimulated by L-triiodothyronine (T3) in both young and aged animals, net activity of the gene in response to the hormone was reduced approximately 2-fold in the aged rats. Next, we wondered …
Authors
Mooradian AD; Fox-Robichaud A; Meijer ME; Wong NCW
Journal
Experimental Biology and Medicine, Vol. 207, No. 1, pp. 97–101
Publisher
Frontiers
Publication Date
October 1, 1994
DOI
10.3181/00379727-207-43797
ISSN
1535-3702