Journal article
A Monoclonal Antibody Against β1 Integrin Inhibits Proliferation and Increases Survival in an Orthotopic Model of High-Grade Meningioma
Abstract
BackgroundHigh-grade meningiomas (HGMs; World Health Organization [WHO] classification grade II and III) have high relapse rates and poor clinical outcomes despite surgery and radiation treatments. No effective medical therapy currently exists for HGMs, and developing novel therapeutic strategies depends on the identification of molecular drivers. In cancer, β1 integrin enhances malignant characteristics, including proliferation, invasion, and …
Authors
Nigim F; Kiyokawa J; Gurtner A; Kawamura Y; Hua L; Kasper EM; Brastianos PK; Cahill DP; Rabkin SD; Martuza RL
Journal
Targeted Oncology, Vol. 14, No. 4, pp. 479–489
Publisher
Springer Nature
Publication Date
8 2019
DOI
10.1007/s11523-019-00654-4
ISSN
1776-2596