Pulmonary embolism and vascular injury: What is the role of thrombin?

Lungs possess dynamic and complex coagulation-thrombolytic and inflammatory sets of innate reactive responses, which generate changes that cause a dramatic alteration in its parenchyma. Clinically, since its steps are reciprocally inter-connected, the pulmonary embolic injury is very complex to describe as one exclusive progression. For example, each step in a coagulation-fibrinolytic-inflammation-integrated pathway produces more side-steps, …