Journal article
Genetic interaction between α4 and β2 subunits of high affinity nicotinic receptor: analysis in schizophrenia
Abstract
Cholinergic dysfunction is one of the hypotheses for the cognitive deficits of schizophrenia. Neurocognitive deficits, which are well-described clinical features of schizophrenia, may be remediated by nicotine; therefore investigations of nicotinic receptor subtypes is of considerable clinical interest. We typed polymorphisms in CHRNA4 and CHRNB2 genes controlling the expression of neuronal high-affinity nicotinic receptors in 117 Canadian …
Authors
De Luca V; Voineskos S; Wong G; Kennedy JL
Journal
Experimental Brain Research, Vol. 174, No. 2, pp. 292–296
Publisher
Springer Nature
Publication Date
9 2006
DOI
10.1007/s00221-006-0458-y
ISSN
0014-4819