Journal article
USP15 regulates type I interferon response and is required for pathogenesis of neuroinflammation
Abstract
Cerebral malaria infection can provoke fatal neuroinflammation. Gros and colleagues identify an ubiquitin-modification axis that exacerbates neuroinflammation and that involves TRIM25 and USP15, which jointly promote type I interferon production.
Authors
Torre S; Polyak MJ; Langlais D; Fodil N; Kennedy JM; Radovanovic I; Berghout J; Leiva-Torres GA; Krawczyk CM; Ilangumaran S
Journal
Nature Immunology, Vol. 18, No. 1, pp. 54–63
Publisher
Springer Nature
Publication Date
January 2017
DOI
10.1038/ni.3581
ISSN
1529-2908
Associated Experts
Fields of Research (FoR)
Sustainable Development Goals (SDG)
Medical Subject Headings (MeSH)
AnimalsDNA-Binding ProteinsEncephalomyelitis, Autoimmune, ExperimentalHEK293 CellsHumansImmunity, InnateInterferon Type IMalaria, CerebralMiceMice, 129 StrainMice, Inbred C57BLMice, TransgenicMolecular Targeted TherapyMyelin-Oligodendrocyte GlycoproteinNeurogenic InflammationPeptide FragmentsPlasmodium bergheiTranscription FactorsUbiquitin-Specific Proteases