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Combinations of antibiotics and nonantibiotic...
Journal article

Combinations of antibiotics and nonantibiotic drugs enhance antimicrobial efficacy

Abstract

The systematic exploration of off-patent drugs in combination with the antibiotic minocycline uncovers unexpected synergies in antibiotic-nonantibiotic pairs. These interactions are exemplified by the nonantibiotic loperamide, which finds a new function in facilitating tetracycline uptake.

Authors

Ejim L; Farha MA; Falconer SB; Wildenhain J; Coombes BK; Tyers M; Brown ED; Wright GD

Journal

Nature Chemical Biology, Vol. 7, No. 6, pp. 348–350

Publisher

Springer Nature

Publication Date

6 2011

DOI

10.1038/nchembio.559

ISSN

1552-4450