Scholarly Works

Combinations of antibiotics and nonantibiotic...

Journal article

Combinations of antibiotics and nonantibiotic drugs enhance antimicrobial efficacy

Abstract

The systematic exploration of off-patent drugs in combination with the antibiotic minocycline uncovers unexpected synergies in antibiotic-nonantibiotic pairs. These interactions are exemplified by the nonantibiotic loperamide, which finds a new function in facilitating tetracycline uptake.

Authors

Ejim L; Farha MA; Falconer SB; Wildenhain J; Coombes BK; Tyers M; Brown ED; Wright GD

Journal

Nature Chemical Biology, Vol. 7, No. 6, pp. 348–350

Publisher

Springer Nature

Publication Date

January 1, 2011

DOI

10.1038/nchembio.559

ISSN

1552-4450

Associated Experts

Brian Coombes

Professor, Faculty of Health Sciences

Eric Brown

Professor, Faculty of Health Sciences

Gerard Wright

Scientific Director, Faculty of Health Sciences

Labels

Fields of Research (FoR)

3101 Biochemistry and cell biology 3404 Medicinal and biomolecular chemistry 34 Chemical Sciences 31 Biological Sciences

Sustainable Development Goals (SDG)

3 Good Health and Well Being

Medical Subject Headings (MeSH)

Anti-Bacterial Agents Drug Evaluation, Preclinical Drug Resistance, Multiple, Bacterial Drug Synergism Drug Therapy, Combination Minocycline

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