Journal article
Sampling the Antibiotic Resistome
Abstract
Microbial resistance to antibiotics currently spans all known classes of natural and synthetic compounds. It has not only hindered our treatment of infections but also dramatically reshaped drug discovery, yet its origins have not been systematically studied. Soil-dwelling bacteria produce and encounter a myriad of antibiotics, evolving corresponding sensing and evading strategies. They are a reservoir of resistance determinants that can be …
Authors
D'Costa VM; McGrann KM; Hughes DW; Wright GD
Journal
Science, Vol. 311, No. 5759, pp. 374–377
Publisher
American Association for the Advancement of Science (AAAS)
Publication Date
January 20, 2006
DOI
10.1126/science.1120800
ISSN
0036-8075
Fields of Research (FoR)
Medical Subject Headings (MeSH)
Amino Acid SubstitutionAnti-Bacterial AgentsCiprofloxacinDaptomycinDrug Resistance, Multiple, BacterialErythromycinGenes, BacterialKetolidesMacrolidesMicrobial Sensitivity TestsMolecular Sequence DataMutationRifampinSoil MicrobiologyStreptomycesTrimethoprim ResistanceVancomycin ResistanceVirginiamycin