Journal article
Role of Homoserine Transacetylase as a New Target for Antifungal Agents
Abstract
Microbial amino acid biosynthesis is a proven yet underexploited target of antibiotics. The biosynthesis of methionine in particular has been shown to be susceptible to small-molecule inhibition in fungi. The first committed step in Met biosynthesis is the acylation of homoserine (Hse) by the enzyme homoserine transacetylase (HTA). We have identified the MET2 gene of Cryptococcus neoformans H99 that encodes HTA (CnHTA) by complementation of an …
Authors
Nazi I; Scott A; Sham A; Rossi L; Williamson PR; Kronstad JW; Wright GD
Journal
Antimicrobial Agents and Chemotherapy, Vol. 51, No. 5, pp. 1731–1736
Publisher
American Society for Microbiology
Publication Date
5 2007
DOI
10.1128/aac.01400-06
ISSN
0066-4804