Journal article
Inhibition of the ANT(2″)-Ia resistance enzyme and rescue of aminoglycoside antibiotic activity by synthetic α-hydroxytropolones
Abstract
Aminoglycoside-2"-O-nucleotidyltransferase ANT(2")-Ia is an aminoglycoside resistance enzyme prevalent among Gram-negative bacteria, and is one of the most common determinants of enzyme-dependant aminoglycoside-resistance. The following report outlines the use of our recently described oxidopyrylium cycloaddition/ring-opening strategy in the synthesis and profiling of a library of synthetic α-hydroxytropolones against ANT(2")-Ia. In addition, …
Authors
Hirsch DR; Cox G; D’Erasmo MP; Shakya T; Meck C; Mohd N; Wright GD; Murelli RP
Journal
Bioorganic & Medicinal Chemistry Letters, Vol. 24, No. 21, pp. 4943–4947
Publisher
Elsevier
Publication Date
11 2014
DOI
10.1016/j.bmcl.2014.09.037
ISSN
0960-894X