Journal article
An Antifungal Combination Matrix Identifies a Rich Pool of Adjuvant Molecules that Enhance Drug Activity against Diverse Fungal Pathogens
Abstract
There is an urgent need to identify new treatments for fungal infections. By combining sub-lethal concentrations of the known antifungals fluconazole, caspofungin, amphotericin B, terbinafine, benomyl, and cyprodinil with ∼3,600 compounds in diverse fungal species, we generated a deep reservoir of chemical-chemical interactions termed the Antifungal Combinations Matrix (ACM). Follow-up susceptibility testing against a fluconazole-resistant …
Authors
Robbins N; Spitzer M; Yu T; Cerone RP; Averette AK; Bahn Y-S; Heitman J; Sheppard DC; Tyers M; Wright GD
Journal
Cell Reports, Vol. 13, No. 7, pp. 1481–1492
Publisher
Elsevier
Publication Date
11 2015
DOI
10.1016/j.celrep.2015.10.018
ISSN
2639-1856