Simplified quantification and reproducibility studies of dopamine D2-receptor binding with iodine-123-IBF SPECT in healthy subjects.

The purpose of this study was to assess the feasibility of a simplified SPECT scan protocol to quantify D2-receptor binding using [123I]iodobenzofuran (IBF) and to evaluate reproducibility of quantitative IBF-SPECT imaging without blood data. METHODS: Twenty healthy volunteers participated in the study, six had test/retest studies separated by 1 wk. Scans were acquired every 5 min for 180 min using a triple-headed SPECT camera after a bolus …