Journal article
Differential actions of nerve growth factor receptors TrkA and p75NTR in a rat model of epileptogenesis
Abstract
Kindling, an experimental model of epileptogenesis, and activation-induced synaptic reorganization are modulated by nerve growth factor (NGF), but whether NGF acts via its high-affinity receptor TrkA and/or the common neurotrophin receptor p75NTR is unknown. We previously demonstrated, and confirmed in this study, that inhibition of NGF binding to both TrkA and p75NTR inhibited kindling and decreased kindling-induced mossy fiber sprouting. We …
Authors
Li S; Saragovi HU; Nedev H; Zhao C; Racine RJ; Fahnestock M
Journal
Molecular and Cellular Neuroscience, Vol. 29, No. 2, pp. 162–172
Publisher
Elsevier
Publication Date
6 2005
DOI
10.1016/j.mcn.2005.02.007
ISSN
1044-7431
Associated Experts
Fields of Research (FoR)
Medical Subject Headings (MeSH)
AnimalsAntibodiesDisease Models, AnimalElectric StimulationEpilepsyGrowth ConesHippocampusKindling, NeurologicMaleMossy Fibers, HippocampalNerve Growth FactorNeuronal PlasticityPeptide FragmentsPerforant PathwayRatsRats, Long-EvansReceptor, Nerve Growth FactorReceptor, trkAReceptors, Nerve Growth Factor