Journal article
Sterol Regulatory Element Binding Protein (SREBP)-1 is a novel regulator of the Transforming Growth Factor (TGF)-β receptor I (TβRI) through exosomal secretion
Abstract
Accumulation of matrix in the glomerulus is a classic hallmark of diabetic nephropathy. The profibrotic cytokine transforming growth factor beta 1 (TGF-β1) plays a central role in the development of glomerular sclerosis. Recent studies have demonstrated that the transcription factor sterol regulatory element binding protein (SREBP)-1 is an important regulator of glomerular sclerosis through both induction of TGF-β1 as well as facilitation of …
Authors
Van Krieken R; Chen G; Gao B; Read J; Al Saleh HA; Li R; Al-Nedawi K; Krepinsky JC
Journal
Cellular Signalling, Vol. 29, , pp. 158–167
Publisher
Elsevier
Publication Date
1 2017
DOI
10.1016/j.cellsig.2016.11.004
ISSN
0898-6568
Associated Experts
Fields of Research (FoR)
Medical Subject Headings (MeSH)
AnimalsCell MembraneDown-RegulationExosomesMaleMembrane MicrodomainsMesangial CellsMice, KnockoutModels, BiologicalProtein BiosynthesisProtein Serine-Threonine KinasesProteolysisRats, Sprague-DawleyReceptor, Transforming Growth Factor-beta Type IReceptors, Transforming Growth Factor betaSignal TransductionSterol Regulatory Element Binding Protein 1Transcription, Genetic