Melatonin Interaction with BZ-GabaA Receptors

The pineal hormone, melatonin, can exert sedative/hypnotic, anxiolytic and other neuropharmacological effects in experimental animals. Usually, these effects are produced by large pharmacological doses of melatonin, which are known to interact with benzodiazepine (BZ) receptors in the central nervous system (CNS). There is evidence that flumazenil, a specific central-type BZ antagonist, can block some of these effects of melatonin. Therefore, …