Journal article
Depressed Fatty Acid and Acetate Oxidation and Other Metabolic Defects in Homogenates from Hearts of Hamsters with Hereditary Cardiomyopathy
Abstract
Metabolic changes in heart homogenate of Syrian hamsters with hereditary cardiomyopathy (BIO 14.6 strain) were examined. Oxidation of labeled fatty acids and acetate by myopathic homogenates was severely depressed; CO 2 production from labeled acetate was only one-fifteenth of the control value, and butyrate oxidation was suppressed to one-fourth of the control value. Although the addition of carnitine enhanced the oxidation of palmitate and …
Authors
KAKO KJ; THORNTON MJ; HEGGTVEIT HA
Journal
Circulation Research, Vol. 34, No. 4, pp. 570–580
Publisher
Wolters Kluwer
Publication Date
April 1974
DOI
10.1161/01.res.34.4.570
ISSN
0009-7330
Fields of Research (FoR)
Medical Subject Headings (MeSH)
AcetatesAcyltransferasesAdenosine TriphosphatasesAnimalsButyratesCaprylatesCarbon DioxideCarbon RadioisotopesCardiomyopathiesCarnitineCathepsinsCoenzyme ACoenzyme A LigasesCricetinaeDNAFatty AcidsGlucuronidaseHexosaminidasesKetoglutaric AcidsMuscle ProteinsMyocardiumOxidation-ReductionPalmitic AcidsPhosphoric Monoester HydrolasesPyruvatesRNASuccinate DehydrogenaseSuccinatesTransferases