Prolonged Inhibition of PGI2 Production and Associatedincreased Thrombogenic Effect in Arteries After Aspirin Administration

In recent studies in rabbits, high dose aspirin (ASA) which inhibited prostacyclin(PG I2) synthesis by veins augmented thrombus formation in jugular veins. This thrombogenic effect was short-lived and lasted only 1-2 hrs. we have shown that the inhibitory effect of ASA on PG I2 synthesis in arteries lasts much longer than in veins. We therefore examined the effects of high dose ASA on arterial thrombosis in rabbits by measuring PG I2 …