Journal article
Donor Pretreatment With Hypertonic Saline Attenuates Primary Allograft Dysfunction
Abstract
BACKGROUND: Hypertonic saline (HTS) has been previously demonstrated to have immune modulatory and vascular protective effects. We assessed the effect of donor pretreatment with HTS on allograft preservation in a porcine model of orthotopic heart transplantation.
METHODS AND RESULTS: Orthotopic transplants were performed after 6 hours of cold static allograft storage. Donor pigs were randomly assigned to pretreatment with (n=7) or without (n=6) …
Authors
Badiwala MV; Ramzy D; Tumiati LC; Tepperman ED; Sheshgiri R; Prodger JL; Feindel CM; Rao V
Journal
Circulation, Vol. 120, No. 11_suppl_1, pp. s206–s214
Publisher
Wolters Kluwer
Publication Date
September 15, 2009
DOI
10.1161/circulationaha.108.843169
ISSN
0009-7322