The Disrupted Steady-State: Tipping the Balance in Favour of Cancer

Genetic changes, such as the activation of oncogenes or the repression of tumour suppressors, contribute to the development of cancer, imparting malignant cells with the potential for self-promoting growth and survival in the presence of anti-growth or pro-apoptotic signals. However, while these changes may initiate the process of cancer development, they are not necessarily sufficient for disease progression, given the body’s intrinsic ability …