Heparin-induced thrombocytopenia

Heparin-induced thrombocytopenia (HIT) is a clinicopathologic syndrome, characterised clinically by thrombocytopenia and a high risk for thrombosis, and pathologically by the formation of heparin-dependent immunoglobulin G that activates platelets via their Fc receptor. The pathogenic antibody causes platelets to generate procoagulant, platelet-derived microparticles in vitro and in vivo; this result in increased thrombin generation and leads …