Evaluation of platelet morphology and the subcellular distribution of PAIgG in patients with ITP and non-immune thrombocytopenia

Studies have shown platelet-associated IgG (PAIgG) is abnormally elevated in idiopathic thrombocytopenic purpura (ITP) and also in thrombocytopenic disorders that are not thought to be immune-mediated. In ITP, PAIgG on the platelet surface is thought to be anti-platelet autoantibody, however the nature of IgG on the surface of platelets of patients with non-immune thrombocytopenia (NIT) is not known. To further investigate these issues we …