Journal article
The role of interleukin‐4Rα in the induction of glutamic acid decarboxylase in airway epithelium following acute house dust mite exposure
Abstract
Background Asthma is a disease characterized by airway inflammation, remodelling and dysfunction. Airway inflammation contributes to remodelling, a term that is used to describe structural changes including goblet cell metaplasia (GCM), matrix deposition, and smooth muscle hyperplasia/hypertrophy. GCM has been implicated in asthma mortality by contributing to mucus plugs and leading to asphyxiation. In animal models, this process is highly …
Authors
Hirota JA; Budelsky A; Smith D; Lipsky B; Ellis R; Xiang Y; Lu W; Inman MD
Journal
Clinical & Experimental Allergy, Vol. 40, No. 5, pp. 820–830
Publisher
Wiley
Publication Date
5 2010
DOI
10.1111/j.1365-2222.2010.03458.x
ISSN
0954-7894