Journal article
Selective cytochrome P450 3A4 inhibitory activity of Amaryllidaceae alkaloids
Abstract
A library of natural and semi-synthetic Amaryllidaceae alkaloids was screened for cytochrome P450 3A4 (CYP3A4) inhibitory activity. Of the crinane, lycorane and galanthamine representatives examined two semi-synthetic silylated lycorane analogues, accessed via a chemoselective silylation strategy from lycorine, and the natural compound narciclasine exhibited low micromolar activities. Important pharmacological features uncovered include the …
Authors
McNulty J; Nair JJ; Singh M; Crankshaw DJ; Holloway AC; Bastida J
Journal
Bioorganic & Medicinal Chemistry Letters, Vol. 19, No. 12, pp. 3233–3237
Publisher
Elsevier
Publication Date
6 2009
DOI
10.1016/j.bmcl.2009.04.086
ISSN
0960-894X