Effect of GST variants on lung function following diesel exhaust and allergen co-exposure in a controlled human crossover study

BACKGROUND: Isolated exposure to diesel exhaust (DE) or allergen can cause decrements in lung function that are impacted by the presence of genetic variants in the glutathione-S-transferase (GST) family but the effect of GST interactions with DE-allergen co-exposure on lung function is unknown. We aimed to assess the impact of DE and allergen co-exposure on lung function and the influence of GSTM1 or GSTT1 variation METHODS: We used a blinded …