Data Monitoring in the Randomized Evaluation of Strategies for Left Ventricular Dysfunction Pilot Study: When Reasonable People Disagree

Randomized Evaluation of Strategies for Left Ventricular Dysfunction (RESOLVD) was a pilot study to examine the effects of various doses of an angiotensin II receptor blocker (ARB) candesartan; an angiotensinconverting enzyme inhibitor (ACE-I) enalapril; and their combination on a number of surrogate outcomes (exercise tolerance, LV function, neurohormones) in patients with congestive heart failure (CHF). A subset of patients was also …