Is There a Relationship Between the Intensity of Heparin Treatment and Recurrent Thomboembolism?

Continuous intravenous heparin is widely used in the initial treatment of patients with venous thromboembolism. However, because it has a narrow therapeutic window and because the anticoagulant response to it varies among patients, it is standard practice to adjust the dose of heparin to achieve a predefined anticoagulant effect (therapeutic range) using the activated partial thromboplastin time (APTT). There is evidence to suggest that the …