Journal article
Effect of activated nitrofurans on DNA
Abstract
Enzymically activated nitrofurazone reacts with co-valently closed circular DNA (derived from Escherichia coli minicells carrying lambdadv) to give at least two kinds of damage: breaks which are detected on neutral sucrose gradients and alkali-labile lesions in DNA which are converted to breaks when the DNA is subsequently Treated with alkali. DNA, isolated from nimicells exposed to the drug, also contains lesions which are converted to breaks …
Authors
Tu Y; McCalla DR
Journal
Biochimica et Biophysica Acta, Vol. 402, No. 2, pp. 142–149
Publisher
Elsevier
Publication Date
August 1975
DOI
10.1016/0005-2787(75)90032-5
ISSN
0006-3002