Journal article
RNA-seq analysis of 2 closely related leukemia clones that differ in their self-renewal capacity
Abstract
The molecular mechanisms regulating self-renewal of leukemia stem cells remain poorly understood. Here we report the generation of 2 closely related leukemias created through the retroviral overexpression of Meis1 and Hoxa9. Despite their apparent common origin, these clonal leukemias exhibit enormous differences in stem cell frequency (from 1 in 1.4, FLA2; to 1 in 347, FLB1), suggesting that one of these leukemias undergoes nearly unlimited …
Authors
Wilhelm BT; Briau M; Austin P; Faubert A; Boucher G; Chagnon P; Hope K; Girard S; Mayotte N; Landry J-R
Journal
Blood, Vol. 117, No. 2, pp. e27–e38
Publisher
American Society of Hematology
Publication Date
January 13, 2011
DOI
10.1182/blood-2010-07-293332
ISSN
0006-4971
Associated Experts
Fields of Research (FoR)
Medical Subject Headings (MeSH)
AnimalsClone CellsFlow CytometryGene Expression ProfilingGene Expression Regulation, LeukemicGenetic VectorsHomeodomain ProteinsLeukemia, Myeloid, AcuteMiceMice, Inbred C57BLMicroarray AnalysisMyeloid Ecotropic Viral Integration Site 1 ProteinNeoplasm ProteinsNeoplastic Stem CellsRetroviridaeReverse Transcriptase Polymerase Chain ReactionSequence Analysis, RNA