Journal article
Subcellular Localization of Cyclic AMP-Responsive Element Binding Protein-Regulated Transcription Coactivator 2 Provides a Link between Obesity and Breast Cancer in Postmenopausal Women
Abstract
Epidemiologic evidence supports a correlation between obesity and breast cancer in women. AMP-activated protein kinase plays an important role in energy homeostasis and inhibits the actions of cyclic AMP-responsive element binding protein-regulated transcription coactivator 2 (CRTC2). In postmenopausal women, the cyclic AMP-responsive element binding protein-dependent regulation of aromatase is a determinant of breast tumor formation through …
Authors
Brown KA; McInnes KJ; Hunger NI; Oakhill JS; Steinberg GR; Simpson ER
Journal
Cancer Research, Vol. 69, No. 13, pp. 5392–5399
Publisher
American Association for Cancer Research (AACR)
Publication Date
July 1, 2009
DOI
10.1158/0008-5472.can-09-0108
ISSN
0008-5472