Journal article
Comprehensive Plasma Metabolomic Analyses of Atherosclerotic Progression Reveal Alterations in Glycerophospholipid and Sphingolipid Metabolism in Apolipoprotein E-deficient Mice
Abstract
Atherosclerosis is the major underlying cause of most cardiovascular diseases. Despite recent advances, the molecular mechanisms underlying the pathophysiology of atherogenesis are not clear. In this study, comprehensive plasma metabolomics were used to investigate early-stage atherosclerotic development and progression in chow-fed apolipoprotein E-deficient mice at 5, 10 and 15 weeks of age. Comprehensive plasma metabolomic profiles, based on …
Authors
Dang VT; Huang A; Zhong LH; Shi Y; Werstuck GH
Journal
Scientific Reports, Vol. 6, No. 1,
Publisher
Springer Nature
DOI
10.1038/srep35037
ISSN
2045-2322