Expression of cd109 with alternate forms of membrane anchoring unique to platelets and megakaryocytic cell lines

CD 109 is a 175 kDa glycoprotein found on platelets, endothelial cells and some cell lines. Alloantibodies to Gov-a/b antigens on CD 109 are implicated in neonatal alloimmune thrombocytopenia and post-transfusion purpura. CD 109 on activated T-cells is associated with helper, but not cytotoxic/suppressor cells. The restricted distribution of CD 109 on platelets, endothelial cells and activated T-cells suggests a role for this protein in cell …