Journal article
Small intestinal bacterial overgrowth and warfarin dose requirement variability
Abstract
The dose of warfarin needed to obtain a therapeutic anticoagulation level varies widely among patients and can undergo abrupt changes for unknown reasons. Drug interactions and genetic factors may partially explain these differences. Intestinal flora produces vitamin K2 (VK2) and patients with small intestinal bacterial overgrowth (SIBO) rarely present reduced INR values due to insufficient dietary vitamin K. The present study was undertaken to …
Authors
Giuliano V; Bassotti G; Mourvaki E; Castellani D; Filippucci E; Sabatino G; Gizzi S; Palmerini F; Galli F; Morelli O
Journal
Thrombosis Research, Vol. 126, No. 1, pp. 12–17
Publisher
Elsevier
Publication Date
7 2010
DOI
10.1016/j.thromres.2009.11.032
ISSN
0049-3848