Cardiac tissue regeneration in bioreactors

Motivation for cardiac tissue regeneration in vitro Myocardial infarction (MI) leads to the death of cardiomyocytes, and the infarct area becomes replaced by a fibroblastic scar tissue that has no contractile function. This reduces the pumping ability of the heart and the cardiac output. In addition, the scar tissue thins due to the lack of vasculature to provide oxygen and nutrients to the infarct site, thus leading to high wall stress and …