The Biological Target Potential of Organometallic Steroids

The discovery of the superfamily of nuclear receptors, represented first by the estrogen receptor (ERα) identified by E.V. Jensen in 1958, caused a veritable revolution in biology. Its repercussions are still with us, in the chemistry of steroids, synthetic selective steroid receptor modulators, and endocrine disruptors. These small molecules, including the group of steroids we will focus on here, can be linked to major diseases (e.g., cancers, …