Journal article
Paracrine Signaling from Breast Cancer Cells Causes Activation of ID4 Expression in Tumor-Associated Macrophages
Abstract
BACKGROUND: Tumor-associated macrophages (TAMs) constitute a major portion of the leukocyte infiltrate found in breast cancer (BC). BC cells may reprogram TAMs in a pro-angiogenic and immunosuppressive sense. We previously showed that high expression of the ID4 protein in triple-negative BC cells leads to the induction of a proangiogenic program in TAMs also through the downregulation of miR-107. Here, we investigated the expression and …
Authors
Donzelli S; Sacconi A; Turco C; Gallo E; Milano E; Iosue I; Blandino G; Fazi F; Fontemaggi G
Journal
Cells, Vol. 9, No. 2,
Publisher
MDPI
DOI
10.3390/cells9020418
ISSN
2073-4409
Associated Experts
Fields of Research (FoR)
Medical Subject Headings (MeSH)
Adaptor Proteins, Signal TransducingAryl Hydrocarbon Receptor Nuclear TranslocatorBreast NeoplasmsCell Line, TumorConnective Tissue Growth FactorCysteine-Rich Protein 61FemaleGene Expression Regulation, NeoplasticHumansInhibitor of Differentiation ProteinsParacrine CommunicationTranscription FactorsTumor-Associated MacrophagesVascular Endothelial Growth Factor AYAP-Signaling Proteins