Journal article
CSB cooperates with SMARCAL1 to maintain telomere stability in ALT cells
Abstract
Elevated replication stress is evident at telomeres of about 10-15% of cancer cells, which maintain their telomeres via a homologous recombination (HR)-based mechanism, referred to as alternative lengthening of telomeres (ALT). How ALT cells resolve replication stress to support their growth remains incompletely characterized. Here, we report that CSB (also known as ERCC6) promotes recruitment of HR repair proteins (MRN, BRCA1, BLM and RPA32) …
Authors
Feng E; Batenburg NL; Walker JR; Ho A; Mitchell TRH; Qin J; Zhu X-D
Journal
Journal of Cell Science, Vol. 133, No. 4,
Publisher
The Company of Biologists
Publication Date
February 15, 2020
DOI
10.1242/jcs.234914
ISSN
0021-9533