Journal article
Complement activity and complement regulatory gene mutations are associated with thrombosis in APS and CAPS
Abstract
The antiphospholipid syndrome (APS) is characterized by thrombosis and/or pregnancy morbidity in the presence of antiphospholipid antibodies, including anti-β2-glycoprotein-I (anti-β2GPI), that are considered central to APS pathogenesis. Based on animal studies showing a role of complement in APS-related clinical events, we used the modified Ham (mHam) assay (complement-dependent cell killing) and cell-surface deposition of C5b-9 to test the …
Authors
Chaturvedi S; Braunstein EM; Yuan X; Yu J; Alexander A; Chen H; Gavriilaki E; Alluri R; Streiff MB; Petri M
Journal
Blood, Vol. 135, No. 4, pp. 239–251
Publisher
American Society of Hematology
Publication Date
January 23, 2020
DOI
10.1182/blood.2019003863
ISSN
0006-4971