Journal article
Evidence of Endoplasmic Reticulum Stress Mediating Cell Death in Transplanted Human Islets
Abstract
A key limitation to the success of islet transplantation is islet cell exhaustion and cell death during islet isolation and following transplantation. Endoplasmic reticulum (ER) stress has been identified as an important mechanism in the development of β-cell dysfunction, cell death, and diabetes. This study investigated the role of ER stress in islet loss during human islet isolation and posttransplantation in a diabetic athymic mouse model. …
Authors
Negi S; Park SH; Jetha A; Aikin R; Tremblay M; Paraskevas S
Journal
Cell Transplantation, Vol. 21, No. 5, pp. 889–900
Publisher
SAGE Publications
Publication Date
May 2012
DOI
10.3727/096368911x603639
ISSN
0963-6897
Fields of Research (FoR)
Medical Subject Headings (MeSH)
Activating Transcription Factor 6AnimalsApoptosisCaspase 3DNA-Binding ProteinsDiabetes Mellitus, ExperimentalEndoplasmic Reticulum Chaperone BiPEndoplasmic Reticulum StressEukaryotic Initiation Factor-2GlucagonHeat-Shock ProteinsHumansInsulinIslets of LangerhansIslets of Langerhans TransplantationMaleMiceMice, NudeMitogen-Activated Protein Kinase 8Regulatory Factor X Transcription FactorsTranscription Factor CHOPTranscription FactorsX-Box Binding Protein 1