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Journal article

Risk of Hospitalization for Serious Adverse Gastrointestinal Events Associated With Sodium Polystyrene Sulfonate Use in Patients of Advanced Age

Abstract

Importance: Sodium polystyrene sulfonate is commonly prescribed for the treatment of hyperkalemia. Case reports of intestinal injury after administration of sodium polystyrene sulfonate with sorbitol resulted in a US Food and Drug Administration warning and discontinuation of combined 70% sorbitol-sodium polystyrene sulfonate formulations. There are ongoing concerns about the gastrointestinal (GI) safety of sodium polystyrene sulfonate use.

Authors

Noel JA; Bota SE; Petrcich W; Garg AX; Carrero JJ; Harel Z; Tangri N; Clark EG; Komenda P; Sood MM

Journal

JAMA Internal Medicine, Vol. 179, No. 8, pp. 1025–1033

Publisher

American Medical Association (AMA)

Publication Date

August 1, 2019

DOI

10.1001/jamainternmed.2019.0631

ISSN

2168-6106