Journal article
Preclinical Assessment of Leptin Transport into the Cerebrospinal Fluid in Diet‐Induced Obese Minipigs
Abstract
OBJECTIVE: A minipig model was employed to explore the changes in endogenous leptin transport into the central nervous system and in hypothalamic sensitivity to exogenous leptin when individuals are placed on high-fat diet (HFD) compared with standard diet.
METHODS: Serum and cerebrospinal fluid (CSF) leptin concentrations during 10 weeks of HFD versus standard diet and exogenous leptin-induced STAT3 phosphorylation in the hypothalamus of …
Authors
Chmielewski A; Hubert T; Descamps A; Mazur D; Daoudi M; Ciofi P; Fontaine C; Caiazzo R; Pattou F; Prevot V
Journal
Obesity, Vol. 27, No. 6, pp. 950–956
Publisher
Wiley
Publication Date
June 2019
DOI
10.1002/oby.22465
ISSN
1930-7381