Journal article
Mechanistic Basis for the Differential Effects of Rivaroxaban and Apixaban on Global Tests of Coagulation
Abstract
Rivaroxaban and apixaban are both small molecules that reversibly inhibit factor Xa. Compared with rivaroxaban, apixaban has minimal effects on the prothrombin time and activated partial thromboplastin time. To investigate this phenomenon, we used a factor Xa-directed substrate in a buffer system. Although rivaroxaban and apixaban inhibited factor Xa with similar K i values at equilibrium, kinetic measurements revealed that rivaroxaban …
Authors
Kim PY; Yeh CH; Dale BJ; Leslie BA; Stafford AR; Fredenburgh JC; Hirsh J; Weitz JI
Journal
TH Open, Vol. 02, No. 02, pp. e190–e201
Publisher
Thieme
Publication Date
April 2018
DOI
10.1055/s-0038-1649507
ISSN
2567-3459