Journal article
Effects of interleukin‐6 receptor blockade on allergen‐induced airway responses in mild asthmatics
Abstract
BACKGROUND: Interleukin (IL)-6 signalling has been implicated in allergic asthma by animal, genetic association and clinical studies. In this study, we tested the hypothesis that tocilizumab (TCZ), a human monoclonal antibody that blocks IL-6 signalling, can prevent the development of allergen-induced bronchoconstriction in humans.
METHODS: We performed a randomised, double-blind, placebo-controlled study, with eligible participants completing …
Authors
Revez JA; Bain LM; Watson RM; Towers M; Collins T; Killian KJ; O'Byrne PM; Gauvreau GM; Upham JW; Ferreira MA
Journal
Clinical & Translational Immunology, Vol. 8, No. 6,
Publisher
Wiley
Publication Date
January 2019
DOI
10.1002/cti2.1044
ISSN
2050-0068