Journal article
Identification of a Botulinum Neurotoxin-like Toxin in a Commensal Strain of Enterococcus faecium
Abstract
Botulinum neurotoxins (BoNTs), produced by various Clostridium strains, are a family of potent bacterial toxins and potential bioterrorism agents. Here we report that an Enterococcus faecium strain isolated from cow feces carries a BoNT-like toxin, designated BoNT/En. It cleaves both VAMP2 and SNAP-25, proteins that mediate synaptic vesicle exocytosis in neurons, at sites distinct from known BoNT cleavage sites on these two proteins. …
Authors
Zhang S; Lebreton F; Mansfield MJ; Miyashita S-I; Zhang J; Schwartzman JA; Tao L; Masuyer G; Martínez-Carranza M; Stenmark P
Journal
Cell Host & Microbe, Vol. 23, No. 2, pp. 169–176.e6
Publisher
Elsevier
Publication Date
February 2018
DOI
10.1016/j.chom.2017.12.018
ISSN
1931-3128