Journal article
Sensory Denervation Reduces Visceral Hypersensitivity in Adult Rats Exposed to Chronic Unpredictable Stress: Evidences of Neurogenic Inflammation
Abstract
The purpose of this study is to provide evidence of neurogenic inflammation in chronic unpredictable stressed rats with the changes of visceral sensitivity, number of mast cells, and close proximity among mast cell-nerve-blood vessels. We found that (1) capsaicin denervation blocked stress-induced increase of visceral sensitivity, while doxantrazole presented a partial blocking; (2) capsaicin denervation blocked stress-induced enhancement of …
Authors
Chen J-H; Wei S-Z; Chen J; Wang Q; Liu H-L; Gao X-H; Li G-C; Yu W-Z; Chen M; Luo H-S
Journal
Digestive Diseases and Sciences, Vol. 54, No. 9, pp. 1884–1891
Publisher
Springer Nature
Publication Date
September 2009
DOI
10.1007/s10620-008-0575-5
ISSN
0163-2116