Journal article
MS analysis of single-nucleotide differences in circulating nucleic acids: Application to noninvasive prenatal diagnosis
Abstract
The analysis of circulating nucleic acids has revealed applications in the noninvasive diagnosis, monitoring, and prognostication of many clinical conditions. Circulating fetal-specific sequences have been detected and constitute a fraction of the total DNA in maternal plasma. The diagnostic reliability of circulating DNA analysis depends on the fractional concentration of the targeted sequence, the analytical sensitivity, and the specificity. …
Authors
Ding C; Chiu RWK; Lau TK; Leung TN; Chan LC; Chan AYY; Charoenkwan P; Ng ISL; Law H-Y; K. ES
Journal
Proceedings of the National Academy of Sciences of the United States of America, Vol. 101, No. 29, pp. 10762–10767
Publisher
Proceedings of the National Academy of Sciences
Publication Date
July 20, 2004
DOI
10.1073/pnas.0403962101
ISSN
0027-8424