Journal article
Fetal hemoglobin in sickle cell anemia: Genetic studies of the Arab-Indian haplotype
Abstract
Sickle cell anemia is common in the Middle East and India where the HbS gene is sometimes associated with the Arab-Indian (AI) β-globin gene (HBB) cluster haplotype. In this haplotype of sickle cell anemia, fetal hemoglobin (HbF) levels are 3-4 fold higher than those found in patients with HbS haplotypes of African origin. Little is known about the genetic elements that modulate HbF in AI haplotype patients. We therefore studied Saudi HbS …
Authors
Ngo D; Bae H; Steinberg MH; Sebastiani P; Solovieff N; Baldwin CT; Melista E; Safaya S; Farrer LA; Al-Suliman AM
Journal
Blood Cells Molecules and Diseases, Vol. 51, No. 1, pp. 22–26
Publisher
Elsevier
Publication Date
June 2013
DOI
10.1016/j.bcmd.2012.12.005
ISSN
1079-9796
Fields of Research (FoR)
Medical Subject Headings (MeSH)
AdolescentAdultAllelesAnemia, Sickle CellArabsCarrier ProteinsChildChild, PreschoolFetal HemoglobinGTP-Binding ProteinsGenes, mybHSP70 Heat-Shock ProteinsHaplotypesHemoglobin, SickleHomeodomain ProteinsHumansKruppel-Like Transcription FactorsLocus Control RegionMiddle AgedMutationNuclear ProteinsPeptide Elongation FactorsPolymorphism, GeneticPromoter Regions, GeneticRepressor ProteinsSequence Analysis, DNATranscription FactorsYoung Adultbeta-Globins