37 GENOME-WIDE ASSOCIATION STUDY OF ALCOHOL USE DISORDER IDENTIFICATION TEST (AUDIT) SCORES IN AN UNSELECTED COHORT OF 20,328 RESEARCH PARTICIPANTS OF EUROPEAN ANCESTRY: RS41973904 AND BEYOND

Background Genetic factors contribute to the risk for developing alcohol use disorder (AUD). Previous studies have estimated the heritability of AUD to be between 40–60% and have explored the role of specific candidate genes, including genes for alcohol-metabolizing enzyme like ADH1B, ALDH2. More recently, Genome-Wide Association Studies (GWAS) have been used to identify risk loci for alcoholism. Methods In collaboration with the genetics …