Journal article
AMP-activated protein kinase: the current landscape for drug development
Abstract
Since the discovery of AMP-activated protein kinase (AMPK) as a central regulator of energy homeostasis, many exciting insights into its structure, regulation and physiological roles have been revealed. While exercise, caloric restriction, metformin and many natural products increase AMPK activity and exert a multitude of health benefits, developing direct activators of AMPK to elicit beneficial effects has been challenging. However, in recent …
Authors
Steinberg GR; Carling D
Journal
Nature Reviews Drug Discovery, Vol. 18, No. 7, pp. 527–551
Publisher
Springer Nature
Publication Date
July 2019
DOI
10.1038/s41573-019-0019-2
ISSN
1474-1776