Journal article
The interleukin-13 paradox in asthma: effective biology, ineffective biologicals
Abstract
Interleukin-13 (IL-13) is a pleiotropic cytokine produced by type-2 helper T-cells (Th2), mast cells and basophils, and is thought to be involved in many of the features of asthma. IL-13 induces many biological responses relevant to asthma, such as B-cell immunoglobulin E production, generation of eosinophil chemoattractants, maturation of mucus-secreting goblet cells, production of extracellular matrix proteins and myofibroblast …
Authors
Nair P; O'Byrne PM
Journal
European Respiratory Journal, Vol. 53, No. 2,
Publisher
European Respiratory Society (ERS)
Publication Date
2 2019
DOI
10.1183/13993003.02250-2018
ISSN
0903-1936